From Otopeni airport: Take DN1 - toward Bucharest, keep streight till Victoriei Square. In Victoriei Square take 3rd exit onto Lascar Catargiu Bvd, keep steight untill Romana Square, continue to Magheru Bvd and reach University Square. Turn first exit to the right, keep streight and at the second traffic light turn right on Brezoianu str. and after 200 m you'll reach Opera Hotel on the right hand side.
by bus - from airport bus 783 to University Square and change to any bus towards Cismigiu Garden bus station. Get off and from there there's a walking distance to Opera Hotel, on Brezoianu str.